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5羟色胺(5-HT)是一种强力的血管活性物质,在高血压的发病机制上被认为能增强其它血管收缩剂(如去甲肾上腺素与血管紧张素Ⅱ)的效应。最近Proutka等利用放射性标测法区别出两种5—HT受体,并发现无论在活体或在试管内只有兴奋5—HT_2受体才出现5—HT的药理和生理效应。Ketanserin是一个特异的5—HT_2
Serotonin (5-HT) is a potent vasoactive substance that is thought to potentiate the effects of other vasoconstrictors (such as norepinephrine and angiotensin II) in the pathogenesis of hypertension. Recently Proutka et al. Used radioimmunoassay to distinguish between two 5-HT receptors and found that the pharmacological and physiological effects of 5-HT appeared only when excited 5-HT2 receptors in vivo or in vitro. Ketanserin is a specific 5-HT_2