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作者在1950年曾经报导了各种血液病患者之血浆对鸡红细胞血红素合成的不同刺激作用,并将引起此种作用的因子命名为“血线素合成增强因子”(“Heme Synthesis Accelerating Factor”)。本文改用鸭红细胞加入甘氨酸及放射性铁的方法来观察此种因子的活力。(以血红素中放射活力表示血红素合成能力)。全部实验以一名正常人之血浆作为对照。作者对下列各类贫血患者血浆中此种因子的活力进行了测定:除一例外八例再生障碍性贫血之血浆中此因子的活力明显增强。在骨髓增生不良之二例,此种因子活力较正常大10倍以上。11例缺铁性贫血之血浆中此因子之活力显著降低,为正常对照组之10—33％。在用铁剂纠正贫血之后,仍不能恢复正常。一例患溶血性贫血,其活力显著增强。一例感染,三例肝脏病、七例肾脏病及三例内分泌病所致之贫血患者血
The authors reported in 1950 that different blood plasma concentrations in hematological patients exert different stimulating effects on hemoglobin synthesis of chicken erythrocytes and named this factor “Heme Synthesis Accelerating Factor” ). In this paper, the use of duck erythrocyte glycine and radioactive iron method to observe the activity of such factors. (Expressed as heme’s heme biosynthesis ability). All experiments with a normal plasma as a control. The authors tested the viability of this factor in the plasma of patients with all types of anemia: the vitality of this factor was significantly enhanced in all but eight of the patients with aplastic anemia. In two cases of myelodysplasia, such factors more than 10 times the normal activity. Eleven patients with iron deficiency anemia significantly reduced the activity of this factor in the plasma, which is 10-33% of the normal control. After using iron to correct anemia, still can not return to normal. A case of hemolytic anemia, its vitality increased significantly. One case of infection, three cases of liver disease, seven cases of kidney disease and three cases of endocrine disease caused by anemia in patients with blood