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在研究天然产物或者在其他有机综合实验中,时常遇到这样的情况:需要将羰基(Carbonylgroup)中的一个氧原子置换为两个氢原子;换句话说,就是要将羰基还原成为亚甲基(Methylenegroup)。提到这样的还原反应,我们往往就想到采用所谓克莱门生还原法(Clemmensen於1913年发现)。这是一个选择性还原羰基为亚甲基的有名方法。主要步骤是:将含羰基的有机化合物悬浮在稀盐酸水溶液中,与锌汞齐混合迴流加热数小时。这个方法固然有它的优点,如对羰基有选择
In the study of natural products or in other organic synthesis experiments, it is often the case that an oxygen atom in a Carbonyl group needs to be replaced by two hydrogen atoms; in other words, the carbonyl group is reduced to a methylene group (Methylenegroup). When it comes to such reductions, we often think of the so-called Clementine reduction method (Clemmensen was discovered in 1913). This is a well-known method for the selective reduction of carbonyls to methylene. The main steps are as follows: suspending the carbonyl-containing organic compound in dilute aqueous hydrochloric acid solution, mixing with zinc amalgam for refluxing for several hours. Although this method has its advantages, such as the choice of carbonyl