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目的和方法：应用99mTc直接法标记抗小鼠宫颈癌（U14）单克隆抗体Au14-1，对荷瘤Km小鼠进行放射性分布和放射免疫显像的实验观察，探讨用99mTc－An14-1作宫颈癌导向诊断和导向治疗的可能性。结果：（1）99mTc－Au14-1注射后12h肿瘤灶已有放射性聚集，24h肿瘤组织的％ID／g值达8．79，呈明显特异性浓聚；（2）除肾脏外，各脏器的T／NT值在2．02~6．71之间，SPECT图像12h已见肿瘤显影，24h肿瘤影像更为清晰。结论：99TcTc－An14-1的体内分布与显像结果相一致，表明An14-1在体内具有良好的宫颈癌导向定位作用。
Objective and Methods: To use 99mTc direct method to label anti-mouse cervical cancer (U14) monoclonal antibody Au14-1, to observe the radioactive distribution and radioimmunoimaging of tumor-bearing Km mice, and to explore the use of 99mTc-An14-1 The possibility of cervical cancer-oriented diagnosis and targeted therapy. RESULTS: (1) The tumor foci at 12h after 99mTc-Au14-1 injection had accumulated radioactively. The %ID/g value of the tumor tissue at 24 h reached 8.79, showing a distinct and specific concentration; (2) Except for the kidney The T/NT value of the device was between 2.02 and 6.71. The SPECT image was seen on the tumor at 12h and the tumor image at 24h was clearer. Conclusion: The in vivo distribution of 99TcTc-An14-1 is consistent with the imaging results, indicating that An14-1 has a good localization of cervical cancer in vivo.