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目的评价草酸铂联合亚叶酸钙和替加氟方案治疗晚期胃癌的疗效与安全性。方法草酸铂130 mg/m2,静脉滴注,第1天;亚叶酸钙150 mg/m2,静脉滴注,第1～5天;替加氟1200 mg/d,分3次口服,总量20 g,21 d为1个周期。结果入组观察70例,其中完全有效4例(5.7%),部分有效24例(34.3%),稳定34例(48.6%),进展8例(11.4%)。总有效率(ORR)为40.0%(28/70),初治ORR为42.9%(18/42),复治ORR为35.7%(10/28),主要不良反应为消化道反应及外周神经毒性。结论草酸钙联合亚叶酸钙、替加氟治疗晚期胃癌近期疗效较高,不良反应轻而且安全。
Objective To evaluate the efficacy and safety of oxaliplatin combined with leucovorin and tegafur in the treatment of advanced gastric cancer. Methods Oxaliplatin 130 mg / m2, intravenous infusion, on the first day; leucovorin 150 mg / m2, intravenous drip, the first 5 days; tegafur 1200 mg / d, orally 3 times, a total of 20 g, 21 d for a period. Results 70 patients were enrolled in the study. Among them, 4 patients were completely effective (5.7%), 24 patients (34.3%) were partially effective, 34 patients (48.6%) were stable, and 8 patients (11.4%) were advanced. The total effective rate (ORR) was 40.0% (28/70), the initial ORR was 42.9% (18/42), and the retreatment ORR was 35.7% (10/28). The main adverse reactions were gastrointestinal reactions and peripheral neurotoxicity . Conclusion Calcium oxalate combined with leucovorin and tegafur in the treatment of advanced gastric cancer have higher efficacy and less adverse reactions and are safe.