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升白宁(对丙烯基苯甲醚,Trans Anethole,Ⅰ)是我国研制成功的新型升白药。国内临床报告证明它对肿瘤放疗或化疗引起的白细胞减少症、苯中毒及各种不明原因的白细胞减少症均具有很好的疗效。升白宁的升白作用机制主要是加速粒细胞的成熟和提前向外周释放。它在体内的代谢主要是通过苯环外共轭双键的断裂,形成苯甲酸被排出体外。升白宁肠溶胶丸作为一种抗癌药辅助药物已被广泛应用于临床。为了寻找比升白宁作用更强、疗效更佳,且口服、注射均有效的药物,我们对升白宁的结构进行了研究,分别对丙烯基侧链及苯环进行了
Sheng Bai Ning (on the methyl benzyl ether, Trans Anethole, Ⅰ) is China’s successful development of a new type of white drug. Domestic clinical reports prove that it has good efficacy on tumor leukemia caused by radiotherapy or chemotherapy, benzene poisoning and various unexplained leukopenia. The mechanism of whitening or white lightening is mainly to accelerate the maturation of granulocytes and release to the periphery in advance. Its metabolism in the body is mainly through the conjugated benzene double bond break, the formation of benzoic acid is excreted. Lining Bai Ning enteric-coated pellets as an anti-cancer drug has been widely used in clinical medicine. In order to find a stronger and better curative effect than aspirin, and the effective oral and injectable drugs, we studied the structure of lignin, respectively, on the propylene side chain and the benzene ring