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Chirality has been extensively studied in interdisciplinary fields for almost two centuries since its ubiquity was discov-ered by Louis Pasteur in 1848,when he successfully separated a pair of enan-tiomers.Indeed,chirality is present at all levels in nature—in the form of sub-atomic particles,macromolecules such as proteins and DNA,microscopic living or-ganisms such as helical bacteria and even in the form of macroscopic objects such as sea shells and spiral galaxies.It is un-deniable that the concept of chirality and the field of stereochemistry,which stud-ies the three-dimensional(3D)struc-ture and relationships of molecules,has had a monumental impact on chemi-cal,biomedical and material sciences[1].Not surprisingly,the design and synthe-sis of an ever-increasing number of small-molecule pharmaceuticals as well as opti-cal materials heavily depend on our deep understanding and exploitation of molec-ular chirality.In chemistry,chirality is di-vided into point/central,spiro,axial,he-lical/planar as well as the multi-layer ver-sions of helical/planar chirality[2].With the exception of multilayer chirality all the other types exist widely in nature.