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冠状动脉损害(CAL)、尤其是冠状动脉瘤是川崎病最严重的并发症。为了预测可能发生CAL的风险,尽早采取措施,使CAL发生率和损伤最大程度减小,文章逐一评述了年龄和性别、发热持续时间、C反应蛋白、血浆N-端脑钠肽前体(NT-pro BNP)、外周血白细胞计数、红细胞沉降率、血浆白蛋白水平、静脉注射丙种球蛋白(IVIG)的时间和剂量、难治性川崎病复发等单一临床特征及实验室指标与CAL发生率的关系。还介绍了原田评分、小林评分评价系统评估CAL风险的应用价值。此外,腱糖蛋白C(TN-C)、micro RNAs(mi RNAs)、基因多态性等实验室指标也在文中有所介绍。
Coronary artery lesions (CALs), and particularly coronary aneurysms, are the most serious complication of Kawasaki disease. In order to predict the risk of possible CAL and to take measures as soon as possible to minimize the incidence and severity of CAL, one article reviews each of age and gender, duration of fever, C-reactive protein, plasma N-terminal pro-brain natriuretic peptide -pro BNP), peripheral blood leukocyte count, erythrocyte sedimentation rate, plasma albumin level, time and dose of intravenous gamma globulin (IVIG), refractory Kawasaki disease recurrence and other single clinical characteristics and laboratory parameters and the incidence of CAL Relationship. Also introduced Harada scoring, Kobayashi scoring system evaluation of the value of CAL risk. In addition, laboratory indices such as tenascin C (TN-C), microRNAs (mi RNAs), and gene polymorphisms are also described in this article.