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目的分析广东省葡萄糖6-磷酸脱氢酶缺乏症(G6PD)与疑似预防接种异常反应(AEFI)发生的关联性。方法采用描述性流行病学和相关性研究方法对广东省2010年新生儿G6PD筛查情况与2010年出生的婴儿接种广东省第1类疫苗后发生AEFI的资料进行相关分析。结果广东省共报告2010年出生的婴儿接种第1类疫苗后发生AEFI个案534例;其中异常反应(253例)占总例数47.38%,一般反应(247例)占46.25%,无急性溶血性个案报告。2010年广东省共有13个地市报告新生儿G6PD缺乏症筛查数据,患病率为0.89%～7.82%,平均报告患病率为2.93%。8个地市2010年出生新生儿G6PD缺乏症患病率与当地2010年出生婴儿接种第1类疫苗后不良反应发生率、一般反应发生率及异常反应发生率之间均无线性相关(P>0.05),与7种广东省第1类疫苗的不良反应发生率之间均无线性相关(P>0.05)。结论该研究未发现广东省被调查地区儿童的G6PD缺乏症患病与第1类疫苗接种后不良反应存在关联。
Objective To analyze the association between glucose-6-phosphate dehydrogenase deficiency (G6PD) and the occurrence of suspected immunization abnormalities (AEFI) in Guangdong Province. Methods A descriptive epidemiological and correlation study was conducted to analyze the correlation between the neonatal G6PD screening in 2010 and the AEFI data of infants born in Guangdong in 2010 after the first class vaccines were vaccinated in Guangdong Province. Results A total of 534 cases of AEFI occurred in infants born in 2010 in Guangdong province. Of these, 534 cases were AEFI (253 cases), 47.25% (46.25%) were general reaction (247 cases), and no acute hemolytic Case report. In 2010, a total of 13 cities in Guangdong Province reported neonatal G6PD deficiency screening data, with a prevalence of 0.89% -7.82% and an average reported prevalence of 2.93%. The prevalence of G6PD deficiency among newborns born in 2010 in 2010 in 2010 in 8 cities was not linearly correlated with the incidence of adverse reactions, incidence of common reactions and incidence of abnormal reactions in the first vaccines of local infants born in 2010 (P> 0.05), and there was no linear correlation between the incidence of side effects and the adverse reactions of the seven kinds of vaccine in Guangdong Province (P> 0.05). Conclusions This study found no association between G6PD deficiency in children in the surveyed areas of Guangdong Province and the adverse reactions after the first vaccination.