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目的:观察3种方案治疗小儿幽门螺旋杆菌(H.Pylori)相关胃病中焦积热症前后症状体征积分分值变化及与疗程的关系,寻找最佳治疗方案。方法:108例H.Pylori胃病患儿按1:1:1对照原则随机分为3组:中药组、西药组和中西药组,每组各36例。中药组口服安幽颗粒(大黄、槟榔、黄连、丹参、香附、白芍);西药组口服克拉霉素、洛赛克;中西药组口服同疗程安幽颗粒加克拉霉素、洛赛克。结果:组内比较:西药组治疗1周与治疗后相比,在总症、主症积分方面均不存在统计学差异(P>0.05);而中药组、中西药组治疗1周与治疗后在主症积分、总症积分方面均存在统计学差异(P<0.01),主症积分、总症积分均有下降。组间比较:治疗1周时中药组与中西药组间在主症积分方面存在统计学差异(P<0.05),而在总症积分方面不存在统计学差异(P>0.05);治疗后主症、总症积分方面不存在统计学差异(P>0.05)(P>0.05),中药组与西药组在治疗1周时主症总症积分、治疗后主症总症积分方面均存在统计学差异(P<0.05,P<0.05,P<0.01,P<0.01)。西药组与中西药组在治疗1周时主症、总症积分,治疗后主症、总症积分方面均存在统计学差异(P<0.01,P<0.01,P<0.01,P<0.01)。结论:中西药结合治疗能明显降低小儿H.Pylori相关胃病中焦积热证主症、总症积分分值,改善临床症状;中药治疗疗效明显与疗程相关,疗程较长者疗效较好。
OBJECTIVE: To observe the changes of symptom and symptom scores before and after coke fever in children with H. pylori related gastropathy and the relationship with the course of treatment, and to find the best treatment plan. Methods: One hundred and eighty children with H. pylori gastritis were randomly divided into three groups according to the 1: 1: 1 control principle: Chinese medicine group, Western medicine group and Chinese and Western medicine group, 36 cases in each group. Chinese medicine group orally take Anyuan granules (rhubarb, areca, berberine, Salvia, Cyperus rotundus, Radix Paeoniae Alba); Western medicine group oral clarithromycin, Losec; . Results: Compared with the control group, there was no significant difference in the total symptom scores and main symptom scores (P> 0.05) between the western medicine group and the western medicine group after one week of treatment and one week after treatment The main symptom scores, total score points were statistically significant (P <0.01), the main symptom scores, the total score decreased. There were significant differences in the main symptom scores between the two groups (P <0.05), but there was no significant difference in the total score (P> 0.05). After treatment, (P> 0.05). There was statistical significance between the scores of main symptoms and the scores of main symptoms after 1 week of treatment in traditional Chinese medicine group and western medicine group (P <0.05, P <0.05, P <0.01, P <0.01). There were significant differences in main symptom, total symptom score, main symptom after treatment, and total symptom score between western medicine group and western medicine group at 1 week of treatment (P <0.01, P <0.01, P <0.01, P <0.01). Conclusion: The combination of traditional Chinese and western medicine can significantly reduce the main symptoms and the total symptom scores in patients with H. pylori related gastropathy, and improve the clinical symptoms. The curative effect of traditional Chinese medicine is obviously related to the course of treatment, while the longer course of treatment is better.