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全身性红斑狼疮(SLE)是好发于女性的一种全身性炎症性疾病,累及多系统,表现异常复杂。病因未明,其发病与遗传、免疫和病毒感染等三个相互联系的因素有关。本病可出现种种自身免疫现象,血清中有抗核抗体等多种自身抗体存在。造成组织炎症和破坏的机理是多方面的,其中,免疫复合物(如DNA—抗DNA免疫复合物)的沉积有着特别重要的意义,与狼疮性肾炎的关系尤为密切。病理上的变化主要是以伴有纤维蛋白样坏死和苏木紫小体存在为特征的结缔组织和血管系统的损害。
Systemic lupus erythematosus (SLE) is a systemic inflammatory disease that occurs in women and affects multiple systems with abnormally complex patterns. Etiology is unknown, its incidence and genetic, immune and viral infection, three interrelated factors. The disease can appear all kinds of autoimmune phenomena, serum anti-nuclear antibodies and other autoantibodies exist. The mechanisms responsible for tissue inflammation and destruction are manifold, with the deposition of immune complexes (such as DNA-anti-DNA immune complexes) of particular importance, especially in relation to lupus nephritis. Pathological changes are mainly the damage of the connective tissue and vascular system characterized by the presence of fibrinoid necrosis and the presence of the photoproteger complex.