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作者leyden从常见的对多种抗生素耐药的感染性湿疹患者皮损处得到的153株金黄色葡萄球菌,并测定了它对各种抗生素的敏感性。结果表明:青霉素和氨苄青霉素耐药性最高(均为88.8%),苯唑青霉素和甲氧酉林均为13.7%,红霉素和四环素分别为16.4%和15.6%,莫匹罗星几乎无耐药性(0%)。20例志愿者的实验性感染显示:外用莫匹罗星软膏(即百多邦)治疗,在抑制金黄色葡萄球菌和化脓性链球菌方面比口服红霉素更为有效.
By leyden 153 strains of Staphylococcus aureus were obtained from lesions of the common infectious eczema patients resistant to multiple antibiotics and tested for their sensitivity to various antibiotics. The results showed that penicillin and ampicillin were the most resistant (both were 88.8%), oxacillin and methicillin were 13.7%, erythromycin and tetracycline were 16.4% and 15.6 %, Mupirocin almost no drug resistance (0%). Experimental infection in 20 volunteers showed that topical mupirocin ointment (ie, Bactroban) was more effective than oral erythromycin in inhibiting S. aureus and S. pyogenes.