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目的探讨胰腺癌合并其他器官恶性肿瘤(胰腺重复癌)的发生率、临床特点及预后情况。方法回顾性分析37例胰腺重复癌患者的临床资料,并对患者生存期进行随访。结果 37例胰腺重复癌患者占同期收治胰腺癌患者的4.5%(37/826)。其中,同时性胰腺重复癌16例,异时性胰腺重复癌21例。37例患者共发生胰腺癌以外恶性肿瘤41个,以胃、结直肠癌最多,分别占22.0%、12.2%。从发现第一肿瘤开始生存计算,37例患者的5年累积生存率为33.6%。异时性胰腺重复癌患者的预后优于同时性胰腺重复癌(P<0.01),胰腺癌发生在前和同时发生患者的预后差于胰腺癌发生在后的患者(P<0.01)。结论胰腺癌诊治过程中应密切注意胰腺重复癌的可能,胰腺癌可能是影响胰腺重复癌预后的主要原因。
Objective To investigate the incidence, clinical features and prognosis of pancreatic cancer combined with other malignant tumors (recurrent pancreatic cancer). Methods The clinical data of 37 patients with recurrent pancreatic cancer were retrospectively analyzed. The patients’ survival was followed up. Results 37 cases of pancreatic cancer patients accounted for 4.5% (37/826) of patients with pancreatic cancer over the same period. Among them, 16 cases of simultaneous pancreatic cancer and 21 cases of synchronous pancreatic cancer. Thirty-seven patients had 41 malignant tumors besides pancreatic cancer, with the most stomach and colorectal cancer accounting for 22.0% and 12.2% respectively. From the discovery of the first tumor, the 5-year cumulative survival rate of 37 patients was 33.6%. The prognosis of patients with synchronous pancreatic cancer is better than that of patients with recurrent pancreatic cancer (P <0.01). The prognosis of patients with pancreatic cancer before and at the same time is worse than that of patients with pancreatic cancer (P <0.01). Conclusion The diagnosis and treatment of pancreatic cancer should pay close attention to the possibility of pancreatic cancer recurrence, pancreatic cancer may affect the prognosis of pancreatic cancer is the main reason.