Separation of Basic Drugs Using Pressurized Capillary Electrochromatography

• 作 者: 张锴 阎超 姚传义 江正瑾 张智超 王琴孙 高如瑜
• 机 构: State Key Laboratory of Elemento Organic Chemistry, Nankai University,Unimicro Technologies Inc.,47
• 出 处: Chinese Journal of Chemistry
• 发表日期: 2003年04期
• 关键词: Tianjin creased instrument Hebei thiourea toluene

A novel pressurized capillary electrochromatography (PCEC) was developed to separate basic drugs on strong cation exchange (SCX) column. The separation result by using PCEC was better than that by using micro HPLC. The effects of electrical field and pressure on plate height and resolution were investigated. Influences of organic modifier, ionic strength and pH value of buffer on retention behavior were evaluated, and the separation mechanism was also discussed.

A novel pressurized capillary electrochromatography (PCEC) was developed to separate basic drugs on strong cation exchange (SCX) column. The separation result by using PCEC was better than that by using micro HPLC. The effects of electrical field and pressure on plate height and resolution were investigated. Influences of organic modifier, ionic strength and pH value of buffer on retention behavior were evaluated as, and the separation mechanism was also discussed.