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氨噻三嗪头孢菌素(Ceftriaxone,Ro13-9904)为一广谱头孢菌素,其血清半衰期较长,约为8小时,蛋白结合率为95％。本文研究了分别给于氨唆三嗓头抱菌素500mg和1500mg后的血清药代动力学、肾排泄和组织液浓度,以观察是否由于剂量增大所致的血清蛋白结合率降低可对药代动力学
Ceftriaxone (Ro13-9904) is a broad-spectrum cephalosporin with a long serum half-life of about 8 hours and a protein binding rate of 95%. This article studies the serum pharmacokinetics, renal excretion, and interstitial fluid concentrations of 500 mg and 1500 mg respectively administered to three amilorrhizin cephalosporins to see if there is a reduction in serum protein binding due to dose escalation dynamics