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６８例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）并发糖尿病肾病（ＤＮ）患者随机分为应用黄蜀葵花醇提物加达美康、开博通（观察组），与用达美康加开博通（对照组）８周疗程对比观察，结果观察组尿微量白蛋白（ｍＡｌｂ），尿蛋白（ＵＰ）定量，血、尿微球蛋白（β２－ｍ），尿Ｎ－乙酰－β－氨基葡萄糖苷酶（ＮＡＧ），血过氧化脂质（ＬＰＯ）和血浆超氧阴离子均较治疗前显著降低（Ｐ＜０．０１～０．００１），且显著低于对照组（Ｐ＜０．０５～０．０１），观察组３１例临床期ＤＮ总有效率８３．８７％，明显高于对照组的３１．０３％（Ｐ＜０．０１），提示黄蜀葵花醇提物对ＤＮ可能有消除氧自由基，减轻肾小管间质病变，改善肾功能．降低蛋白尿的作用。
Sixty-eight patients with non-insulin-dependent diabetes mellitus (DN) complicated with diabetic nephropathy (DN) were randomly divided into two groups: control group (control group) ) 8-week course of treatment, the results of the observation group of urine microalbumin (mAlb), urine protein (UP) quantitative, blood, urine microglobulin (β2-m), urine N-acetyl-β- glucosaminidase ), LPO and plasma superoxide anion were significantly lower than those before treatment (P <0.01 ~ 0.001), and were significantly lower than those of the control group (P <0.05 ~ 0.01) . The total effective rate of clinical DN in 31 cases of observation group was 83.87%, which was significantly higher than that of control group (31.03%) (P <0.01), which indicated that alcohol extract of Populus tomentosa could eliminate oxygen free radicals and alleviate Tubulointerstitial lesions, improve renal function. Reduce the role of proteinuria.