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目的研究乙型肝炎免疫球蛋白联合乙型肝炎疫苗在乙型肝炎病毒(HBV)母婴传播合并感染新生儿中的阻断效果,为降低感染率提供依据。方法选取2013年6月-2015年8月医院诊治的HBsAg阳性孕妇分娩的220例新生儿资料进行分析,采用随机对照方法将新生儿分为对照组和试验组,每组110例;对照组单独接种乙型肝炎疫苗,试验组联合应用乙型肝炎免疫球蛋白,比较两组新生儿HBV阻断效果,采用SPSS18.0软件对采集的数据进行统计分析。结果试验组102例新生儿HBV阻断成功,阻断率为93.33%,对照组90例新生儿HBV阻断成功,阻断率为81.8%,试验组显著高于对照组,差异有统计学意义(P<0.05);试验组免疫保护率为99.1%,显著高于对照组,差异有统计学意义(P<0.05);试验组在不同HBeAg状态、DNA载量、HBsAg滴度状态下阻断率显著高于对照组,差异有统计学意义(P<0.05)。结论 HBV母婴传播合并新生儿在乙型肝炎疫苗基础上联合乙型肝炎免疫球蛋白效果理想,能够提高临床阻断率,降低母婴垂直传播,值得推广应用。
Objective To study the blocking effect of hepatitis B immunoglobulin combined with Hepatitis B vaccine on newborn infants with hepatitis B virus (HBV) infection and to provide basis for reducing the infection rate. Methods The data of 220 newborns delivered by HBsAg positive pregnant women hospitalized from June 2013 to August 2015 were analyzed. The neonates were divided into control group and trial group with 110 cases in each group by randomized control. The control group alone Inoculation of hepatitis B vaccine, the experimental group combined with hepatitis B immunoglobulin, compared two groups of neonatal HBV blocking effect, the use of SPSS18.0 software for statistical analysis of the collected data. Results In the experimental group, 102 cases of newborns were successfully blocked with HBV, the blocking rate was 93.33%. In the control group, 90 cases of newborns were successfully blocked by HBV with a blocking rate of 81.8%. The experimental group was significantly higher than that of the control group with statistically significant difference (P <0.05). The immune protection rate in the experimental group was 99.1%, which was significantly higher than that in the control group (P <0.05). The experimental group was blocked in different HBeAg status, DNA load and HBsAg titers The rate was significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusion The combination of HBV mother-to-infant transmission and newborn babies with hepatitis B vaccine based on hepatitis B immunoglobulin is effective and can improve the clinical blocking rate and reduce the vertical transmission of mother and baby, which is worth popularizing and applying.