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目的:观察奥扎格雷钠在治疗脑梗死患者中的辅助作用。方法:将我科2008年1月至2010年4月收治的168例脑梗死患者随机分为两组,对照组采用常规治疗,口服肠溶阿斯匹林、阿托伐他汀,静滴胞二鳞胆碱、血塞通等。治疗组在对照组治疗的基础上加用奥扎格雷钠冻干粉针剂。观察两组患者进展性脑梗死的发生率和神经功能缺损评分。结果:治疗组急性脑梗死疗效好,其进展性脑梗死发生率与对照组相当,无统计学意义。两组神经功能有显著性改善,治疗组较对照组明显(P<0.05),且治疗组总有效率明显优于对照组(P<0.05),其副作用较轻,均能耐受。结论:奥扎格雷钠能抑制大脑血管痉挛,增加大脑血流量,改善大脑的微循环和能量代谢,提高了急性期脑梗死的总有效率,且神经功能有明显改善,值得临床应用。
Objective: To observe the role of ozagrel in the treatment of patients with cerebral infarction. Methods: A total of 168 patients with cerebral infarction who were admitted to our department from January 2008 to April 2010 were randomly divided into two groups. The control group was treated with routine therapy, oral enteric-coated aspirin, atorvastatin, Choline, Xuesaitong and so on. Treatment group in the control group based on the addition of sodium ozagrel sodium freeze-dried powder. The incidence of progressive cerebral infarction and neurological deficit scores in both groups were observed. Results: The curative effect of acute cerebral infarction in treatment group is good, and the incidence of progressive cerebral infarction is comparable with that in control group, with no statistical significance. The neurological function of the two groups was significantly improved, the treatment group than the control group was significantly (P <0.05), and the total effective rate was significantly better than the control group (P <0.05), the side effects were mild, can tolerate. Conclusion: Ozagrel sodium can inhibit cerebral vasospasm, increase cerebral blood flow, improve cerebral microcirculation and energy metabolism, improve the total effective rate of acute cerebral infarction, and improve neurological function, which is worthy of clinical application.