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乙胺碘呋酮用于抗心律失常已十多年了,其主要电生理学特点是延长心肌细胞的动作电位时间,而不改变膜静息电位;抑制4相除极,延长心肌复极,并且有去颤作用,故将其归为Ⅲ类抗心律失常药。不仅能有效地终止室上性心律失常,且能成功地治疗致命性心律失常。近来有人提出此药尚能预防室颤的发生。本药半衰期长,平均为30天(15—100天),容易蓄积,但其半数致死量为治疗剂量的9倍以上,故毒性
Amiodarone has been used for anti-arrhythmia for more than a decade, and its main electrophysiological feature is to prolong the action potential time of cardiomyocytes without changing the resting potential of the membrane; to inhibit 4-phase depolarization, to prolong myocardial repolarization, and Defibrillation effect, so it is classified as Class III anti-arrhythmic drugs. Not only can effectively terminate supraventricular arrhythmias, and can successfully treat fatal arrhythmias. Recently, it was suggested that this drug can prevent the occurrence of ventricular fibrillation. The drug has a long half-life, an average of 30 days (15-100 days), easy to accumulate, but the median lethal dose of more than 9 times the therapeutic dose, so the toxicity