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慢性乙肝病毒(HBV)感染是原发性肝癌(HCC)发生发展的一个主要的危险因素。乙型肝炎病毒X蛋白(HBx)与HCC的形成密切相关,其反式激活功能被认为是HBV与HCC关联的主要因素。HBx的自然突变普遍存在于肝癌患者中,HBx突变在HCC中可能起关键作用。
Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of primary liver cancer (HCC). Hepatitis B virus X protein (HBx) is closely related to the formation of HCC, and its transactivation function is considered as the main factor associated with HBV and HCC. Natural mutations in HBx are common in patients with liver cancer, and HBx mutations may play a key role in HCC.