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尿毒症的出血是多因素的。尿毒症血浆中积聚的中分子物质抑制了血小板的聚集,而前列环素的增加,则可干扰血小板与血管壁之间的相互作用。Remuzzi等人报道了天然的牛甲状旁腺激素(PTH)明显地抑制体外不同刺激产生的血小板聚集和分泌,表明PTH是一种主要的尿毒症毒素,本文采用几种纯的PTH制剂,研究其对血小板聚集的影响。研究所用的合成肽为:牛PTH1-84、人PTH1-44、28-48、和53-84及人PTH1-34。对照组为20名健康男性,年龄在20～35岁,试验前4周内未服用任何药物;病人组系6例原发性甲状旁腺机能亢
Uremic bleeding is multifactorial. Mucopolysaccharides accumulate in uremia inhibit platelet aggregation, whereas increased prostacyclin interferes with platelet-vessel wall interactions. Remuzzi et al. Reported that natural bovine parathyroid hormone (PTH) significantly inhibits platelet aggregation and secretion by different stimuli in vitro, indicating that PTH is a major uremic toxin. Several pure PTH preparations were used in this study to study Impact on platelet aggregation. The synthetic peptides used in the study were: cow PTH1-84, human PTH1-44, 28-48, and 53-84 and human PTH1-34. Control group of 20 healthy men, aged 20 to 35 years, 4 weeks before the test did not take any drugs; the patient group of 6 patients with primary hyperparathyroidism