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目的:对注射用丹参多酚酸盐治疗急性脑梗死患者的临床疗效及对患者神经功能的保护作用和ET-1水平的影响进行分析。方法:收集2016年1月—2016年12月急性脑梗死患者100例随机分两组。对照组采用常规神经内科治疗方法,干预组在对照组基础上给予注射用丹参多酚酸盐治疗。比较两组患者急性脑梗死治疗总有效率;药物不良反应发生率;治疗前和治疗后患者全血比黏度、红细胞聚集指数、血浆比黏度、ET-1水平的差异。治疗前和治疗后患者神经功能缺损评分、脑血管储备能力、屏气指数的差异。结果:干预组患者急性脑梗死治疗总有效率96.00%高于对照组76.00%,χ2=4.153,P<0.05。治疗前两组神经功能缺损评分、脑血管储备能力、屏气指数比较无显著差异。干预组分别为26.15±1.01、18.62±3.15、0.81±0.12,对照组分别为26.52±0.91、18.24±3.31、0.82±0.16,P>0.05;治疗后干预组神经功能缺损评分、脑血管储备能力、屏气指数改善幅度更大,干预组分别为10.76±0.51、36.55±5.99、1.45±0.24,对照组分别为15.11±1.24、22.15±5.41、1.01±0.37,P<0.05。干预组药物不良反应发生率和对照组对比,发生率均为8.00%,差异不显著,χ2=0.000,P>0.05。治疗前两组全血比黏度、红细胞聚集指数、血浆比黏度、ET-1水平比较无显著差异,干预组分别为5.72±0.67、11.25±0.71、1.92±0.42、74.01±6.22,对照组分别为5.67±0.61、11.21±0.81、1.94±0.41、74.01±6.21,P>0.05;治疗后干预组全血比黏度、红细胞聚集指数、血浆比黏度、ET-1水平改善幅度更大,干预组分别为4.21±0.51、9.22±0.26、1.53±0.19、61.55±1.59,对照组分别为5.43±0.29、10.45±0.22、1.82±0.34、67.48±4.34,P<0.05。结论:注射用丹参多酚酸盐治疗急性脑梗死患者的临床疗效及对患者神经功能的保护作用和ET-1水平的影响大,可有效改善患者临床症状和神经功能,促进ET-1水平降低,改善患者血液流变学特性,对患者预后有益,值得推广。
OBJECTIVE: To analyze the clinical efficacy of Salviae miltiorrhizae polyphenols for the treatment of patients with acute cerebral infarction and its protective effect on neurological function and ET-1 level. Methods: One hundred patients with acute cerebral infarction from January 2016 to December 2016 were randomly divided into two groups. The control group was treated by conventional neurology. The intervention group was given Salviae miltiorrhizae polyphenols for injection on the basis of the control group. The total effective rate of acute cerebral infarction was compared between two groups. The incidence of adverse drug reactions, the whole blood viscosity, erythrocyte aggregation index, plasma specific viscosity and ET-1 level before and after treatment were compared. Differences in neurological deficit score, cerebrovascular reserve capacity and breath hold index before and after treatment were observed. Results: The total effective rate of acute cerebral infarction in intervention group was 96.00% higher than that in control group (76.00%, χ2 = 4.153, P <0.05). There was no significant difference between the two groups in neurological deficit score, cerebrovascular reserve capacity and breath hold index before treatment. The intervention group were 26.15 ± 1.01,18.62 ± 3.15,0.81 ± 0.12, the control group were 26.52 ± 0.91,18.24 ± 3.31,0.82 ± 0.16, P> 0.05; after treatment, the neurological deficit score, cerebrovascular reserve capacity, The improvement of breath holding index was larger in the intervention group, 10.76 ± 0.51,36.55 ± 5.99 and 1.45 ± 0.24 in the intervention group and 15.11 ± 1.24, 22.15 ± 5.41 and 1.01 ± 0.37 in the control group, P <0.05. The incidence of adverse drug reactions in the intervention group and the control group, the incidence was 8.00%, the difference was not significant, χ2 = 0.000, P> 0.05. There was no significant difference in the whole blood viscosity, erythrocyte aggregation index, plasma specific viscosity and ET-1 level between the two groups before treatment, the intervention groups were 5.72 ± 0.67, 11.25 ± 0.71, 1.92 ± 0.42 and 74.01 ± 6.22, respectively 5.67 ± 0.61,11.21 ± 0.81,1.94 ± 0.41,74.01 ± 6.21, P> 0.05. After treatment, the whole blood viscosity, erythrocyte aggregation index, plasma specific viscosity and ET-1 level in intervention group were improved more significantly than those in intervention group 4.21 ± 0.51,9.22 ± 0.26,1.53 ± 0.19,61.55 ± 1.59, respectively, the control group were 5.43 ± 0.29,10.45 ± 0.22,1.82 ± 0.34,67.48 ± 4.34, P <0.05. Conclusion: Salviae miltiorrhizae polyphenols can effectively improve the clinical symptoms and neurological function, and decrease ET-1 level in patients with acute cerebral infarction and its protective effects on neurological function and ET-1 level. , Improve the patient’s blood rheology, the prognosis of patients is beneficial, it is worth promoting.