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抗磷脂抗体包括抗心脂抗体(ACA)、狼疮抗凝因子(LAC)等。近来抗磷脂抗体与血栓症的关系引起人们注意。当时这类抗体的发现是在系统性红斑狼疮(SLE)患者,以后非 SLE 患者中也有报告。Harris及 Hugres 最近提出将抗磷脂抗体阳性的血栓症称为抗磷脂抗体症侯群的概念,但未确定其诊断标准。此外,有关抗磷脂抗体在血栓形成中的机理以及抗体阳性患者临床特征也不十分清楚,特别是对没有胶原病为原发疾病的脑梗塞患者的研究极少。本文则测定非胶原病患者抗磷脂抗体之 ACA,对结果阳性与阴性的脑梗塞患者临床及血凝学的差异作研究。研究对象为随机连续入院经 CT 确诊的脑梗塞患者72例,男50例,女22例,年龄29～90岁,平均66±14岁。符合胶原病等诊断者除外。全部病例均用ELISA 法作 ACA(IgM,IgG 抗体)测定,同时进行出凝
Antiphospholipid antibodies include anti-lipid antibodies (ACA), lupus anticoagulant factor (LAC) and so on. Recently the relationship between antiphospholipid antibodies and thrombosis aroused people’s attention. At that time, the discovery of such antibodies was reported in patients with systemic lupus erythematosus (SLE) and non-SLE patients in the future. Harris and Hugres recently proposed the concept of anti-phospholipid-antibody-positive thrombosis as an anti-phospholipid antibody syndrome but did not establish its diagnostic criteria. In addition, the anti-phospholipid antibodies in the pathogenesis of thrombosis and antibody-positive patients with clinical features are not very clear, especially in the absence of collagen disease as the primary disease in patients with cerebral infarction rarely. In this paper, non-collagen disease patients with anti-phospholipid antibodies ACA, positive and negative outcomes in patients with cerebral infarction clinical and hematological differences for the study. The subjects were randomized consecutive hospitalized 72 cases of cerebral infarction confirmed by CT, 50 males and 22 females, aged 29 to 90 years, mean 66 ± 14 years. Except for diagnoses such as collagen disease. All cases were assayed by ELISA for the determination of ACA (IgM, IgG antibody) and coagulation at the same time