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While the association between obesity, type 2 diabetes (T2D) and the presence of steatosis has been established since the beginning of the last century (1), it was not until 1980 that the first references were made about a form of histologic liver lesion designated as non-alcoholic steatohepatitis (NASH). NASH is characterised by the presence of a variable degree of steatosis accompanied by lobular inflammatory infiltrate and hepatocellular damage with or without fibrosis. Subsequently, the broader term of non-alcoholic fatty liver disease (NAFLD) was accepted, which more accurately encompass the entire spectrum of lesions that appear in these patients (2). Ever since then, NAFLD has become progressively the primary cause of chronic liver disease in developed countries (3).