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目的了解河南地区产前筛查21-三体综合征的现状,提高产前超声筛查21-三体综合征的灵敏度和特异度。方法对在郑州大学第三附属医院行产前诊断的4 136名孕妇资料进行回顾性分析。结果产前超声筛查先天性异常的总检出率为5.8%,产前超声筛查21-三体综合征的灵敏度、特异度分别为57.1%、57.5%,且21-三体综合征的筛查阳性率逐年提高。结论加强产前超声的规范化筛查及管理,完善诊疗规范,提高21-三体综合征胎儿的灵敏度、特异度。
Objective To investigate the status of prenatal screening for trisomy 21 in Henan Province and to improve the sensitivity and specificity of prenatal ultrasound screening for trisomy 21 syndrome. Methods The data of 4 136 pregnant women who were diagnosed prenatally in the Third Affiliated Hospital of Zhengzhou University were analyzed retrospectively. Results The overall detection rate of prenatal ultrasound screening for congenital anomalies was 5.8%. The sensitivity and specificity of prenatal ultrasound screening for trisomy 21 were 57.1% and 57.5%, respectively, and the positive rates of trisomy 21 Screening positive rate increased year by year. Conclusion To strengthen the standardization of prenatal ultrasound screening and management, improve the diagnosis and treatment of norms to improve the sensitivity of the fetus 21-trisomy syndrome, specificity.