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业已证明,携带HBsAg的母亲能将乙型肝炎病毒(HBV)传染给她们的婴儿。如母亲为HBeAg阳性,则婴儿感染率特别高;如母亲为抗-HBe阳性,则婴儿感染率较低。作者为了评价用乙型肝炎免疫球蛋白(HBIG)加乙型肝炎疫苗预防HBsAg阳性母亲所生婴儿感染乙型肝炎的效果,进行了试验。试验对象为HBsAg阳性母亲所生的92名健康婴儿,其中49名婴儿(53.3%)的母亲HBeAg阳性;30名婴儿(32.6%)的母亲抗-HBe阳性,而且谷丙转氨酶异常;13名婴儿(14.1%)的母亲HBeAg和抗-HBe均阴性。所有婴儿在出生当天和出生后1个月肌肉注射
It has been demonstrated that mothers carrying HBsAg can transmit hepatitis B virus (HBV) to their infants. If the mother is HBeAg-positive, the infection rate is particularly high in infants; if the mother is anti-HBe positive, the infection rate in infants is low. The authors tested the efficacy of hepatitis B immunoglobulin (HBIG) plus hepatitis B vaccine in preventing hepatitis B infection in infants born to HBsAg-positive mothers. Ninety-two infants (53.3%) were HBeAg-positive mothers; 30 infants (32.6%) were anti-HBe-positive and alanine aminotransferase was abnormal; 13 infants (14.1%) of mothers were negative for both HBeAg and anti-HBe. All infants are injected intramuscularly on the day of birth and one month after birth