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目的探讨类风湿关节炎(rheumatoid arthritis,RA)患者合并贫血的类型及其相关因素。方法选取衢州市人民医院2012年1月—2014年12月3年间确诊的RA患者,在清晨空腹状态下,抽取静脉血送实验室进行相关指标检查。将得到的资料进行统计分析。结果合并慢性病性贫血(chronic disease anemia,ADC)27例,占总贫血的47.37%(27/57),缺铁性贫血(iron deficiency anemia,IDA)20例,占总贫血的35.09%(20/57),巨幼细胞性贫血(MA)10例,占总贫血的17.54%(10/57)。女性贫血发生率显著高于男性(P<0.05)。ADC患者与无贫血患者比较,强的松的用量显著增加(P<0.05),MA患者年龄显著高于无贫血患者(P<0.05);ADC患者与无贫血患者比较,病情活动度、血沉、C反应蛋白均显著增高(P均<0.05)。结论 RA患者合并贫血的类型主要是慢性病性贫血和缺铁性贫血,与长期口服药物、病情活动度、血沉、C反应蛋白可能有关,RA患者并发贫血还需警惕和预防恶病质的出现,通过饮食增加营养摄入,补充蛋白质、维生素和矿物质,这对预防和避免贫血能起到重要作用。
Objective To investigate the types of anemia associated with rheumatoid arthritis (RA) and its related factors. Methods The patients with RA diagnosed in Quzhou People’s Hospital from January 2012 to December 2014 were enrolled in this study. The data obtained for statistical analysis. Results 27 cases were complicated with chronic disease anemia (ADC), accounting for 47.37% (27/57) of total anemia and 20 cases of iron deficiency anemia (IDA) accounting for 35.09% (20 / 57), megaloblastic anemia (MA) 10 cases, accounting for 17.54% (10/57) of the total anemia. The incidence of anemia in women was significantly higher than that in men (P <0.05). Compared with those without anemia, the dosage of prednisone significantly increased (P <0.05), the age of MA patients was significantly higher than that of patients without anemia (P <0.05); The activity of patients with ADC, ESR, C-reactive protein were significantly increased (P all <0.05). Conclusion The main types of anemia associated with RA are chronic aplastic anemia and iron deficiency anemia, which may be related to long-term oral medication, disease activity, erythrocyte sedimentation rate and C-reactive protein. The occurrence of anemia in patients with RA needs to be vigilant and prevent the occurrence of cachexia. Increasing nutritional intake and supplementing proteins, vitamins and minerals can play an important role in preventing and avoiding anemia.