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本文报道了黄芪和黄芪多糖对正常和大黄脾虚模型小鼠巨噬细胞产生IL—1的影响。实验结果表明:黄芪(0.5kg/L,体内)、黄芪多糖(1.25×10~4mg/L,体外)可协同LPS使正常小鼠IL—1活性提高;大黄脾虚小鼠IL—1活性此正常小鼠低;黄芪(0.5～2kg/L体内)、黄芪多糖(1.25×10~4～1.00×10~3mg/L体外)均可协同LPS使脾虚低下的IL—1明显提高;黄芪或黄芪多糖分别单独作用于正常及大黄脾虚小鼠,未测出有意义的IL—1活性。本研究为黄芪在临床上的运用提供了部分科学依据,也有助于进一步认识脾虚机体的免疫功能变化机理。
This article reports the effect of Astragalus membranaceus and Astragalus polysaccharides on the production of IL-1 by macrophages in normal and rhubarb spleen-model mice. The experimental results showed that the activity of IL-1 in normal mice was enhanced by LPS in response to LPS (0.5 kg/L in vivo) and Astragalus polysaccharide (1.25×10~4 mg/L in vitro). The activity of IL-1 in Rheum spleen mice was normal. The mice were low; Astragalus (0.5-2kg/L in vivo) and Astragalus polysaccharides (1.25×10~4～1.00×10-3mg/L in vitro) were all synergistic with LPS to significantly increase IL-1 in spleen deficiency; Astragalus or Astragalus polysaccharides The mice were treated with normal and rhubarb spleen alone and no significant IL-1 activity was detected. This study provides some scientific basis for the clinical application of Astragalus membranaceus, and it also helps to further understand the mechanism of immune function changes in spleen deficiency.