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目的探讨硫氧还蛋白相互作用蛋白(TXNIP)与2型糖尿病(T2DM)及胰岛素抵抗的关系。方法采用ELISA法检测T2DM组(A组,54例)及正常对照组(B组,30例)患者血清TXNIP水平,同时检测糖化血红蛋白(HbA1c)、空腹血糖(FPG)、胰岛素(FINS)及血脂。结果 A组血清TXNIP水平显著高于B组(P<0.05)。TXNIP与FPG、HbA1c、胰岛素抵抗指数(HOMA-IR)呈显著正相关(P<0.01);HbA1c和HOMA-IR是TXNIP的独立影响因素。结论 TXNIP可能参与了T2DM及胰岛素抵抗的病理生理过程。
Objective To investigate the relationship between thioredoxin interacting protein (TXNIP) and type 2 diabetes mellitus (T2DM) and insulin resistance. Methods Serum levels of TXNIP in T2DM group (54 cases) and normal control group (30 cases in group B) were detected by ELISA. HbA1c, FPG, FINS and serum lipids . Results The level of serum TXNIP in group A was significantly higher than that in group B (P <0.05). TXNIP was positively correlated with FPG, HbA1c and insulin resistance index (HOMA-IR) (P <0.01). HbA1c and HOMA-IR were independent factors of TXNIP. Conclusion TXNIP may be involved in the pathophysiological process of T2DM and insulin resistance.