论文部分内容阅读
本文报道米非司酮四种抗早孕用药方案对孕妇血凝-纤溶系统九种参数(PT、KPTT、VⅡ:C、VⅢ:C、VWF、ATⅢ:C、ATⅢ:Ag 以及α2-MG、Pg 抗原水平)的影响。应用SAS 统计软件包对实验数据进行统计分析。结果显示:四组间用药前每一种参数值均无显著差异,四组间相同时间PT、KPTT、ATⅢ:Ag 和α2-MG 水平无显著差异。组Ⅱ(50mg×6)作用较明显,VⅡ:C、VⅢ:C 分别明显低于组Ⅰ(50mg)和组Ⅲ(200mg)。此外,组Ⅱ和组Ⅳ(600mg)的VWF 明显低于其他两组。结果提示米非司酮抗早孕时低剂量多次用药(50mg×6)对血凝-纤溶的影响比大剂量(600mg)一次用药明显,其综合效应是具有抑制凝血活性的倾向。但结合临床,这种作用并不是导致出血过多或时间过长的主要原因。
In this paper, we report the effects of mifepristone on the nine parameters of the coagulation-fibrinolytic system (PT, KPTT, VⅡ: C, VⅢ: C, VWF, ATⅢ: C, ATⅢ: Ag and α2-MG, Pg antigen level). SAS statistical software package for statistical analysis of experimental data. The results showed that there was no significant difference between the four groups before treatment, and there was no significant difference in PT, KPTT, ATⅢ: Ag and α2-MG at the same time among the four groups. The effect of group Ⅱ (50mg × 6) was more obvious than that of group Ⅰ (50mg) and group Ⅲ (200mg). In addition, VWF was significantly lower in Groups II and IV (600 mg) than in the other two groups. The results suggest that mifepristone anti-early pregnancy low-dose multiple drug (50mg × 6) on the coagulation-fibrinolysis than a large dose (600mg) a significant drug use, the combined effect of inhibition of coagulation activity tendency. But combined with clinical, this effect is not the main reason leading to excessive bleeding or prolonged time.