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目的:探讨血清总胆红素(T-BIL)、尿酸(UA)、超敏C反应蛋白(hsCRP)在急性脑梗死(ACI)诱发全身炎症反应综合征(SIRS)中的作用。方法:应用全自动生化分析仪,分别在发病24h内和第14天测定60例ACI致SIRS患者(SIRS组)、64例急性单纯ACI患者(SACI组)及60名健康体检者(对照组)血清T-BIL、UA、hsCRP含量。结果:SIRS组患者在发病后14d内有7例死亡。发病24h内,SACI组和SIRS组血清UA、hsCRP均升高,治疗后降低(P<0.05),SIRS组升高更明显(P<0.05)。血清T-BIL仅在SIRS组升高,治疗后恢复至正常(P<0.05)。结论:ACI进展为SIRS后,患者T-BIL、UA、hsCRP明显升高,病情缓解后可以减低,可作为诊断和评估病情的一项指标。
Objective: To investigate the role of serum total bilirubin (T-BIL), uric acid (UA) and high sensitivity C-reactive protein (hsCRP) in systemic inflammatory response syndrome (SIRS) induced by acute cerebral infarction (ACI). Methods: Sixty ACI-induced SIRS patients (SIRS group), 64 acute ACI patients (SACI group) and 60 healthy volunteers (control group) were detected by automatic biochemical analyzer at 24 hours and 14 days respectively. Serum T-BIL, UA, hsCRP content. Results: Seven patients died within 14 days after onset in the SIRS group. Serum UA and hsCRP in SACI group and SIRS group increased within 24 hours after onset, decreased after treatment (P <0.05), and increased more significantly in SIRS group (P <0.05). Serum T-BIL increased only in the SIRS group and returned to normal after treatment (P <0.05). Conclusion: After the progression of ACI to SIRS, the T-BIL, UA and hsCRP levels in patients with acute myocardial infarction were significantly higher than those in patients with mild to moderate ischemic stroke and could be reduced after remission. It could be used as an index to diagnose and evaluate the disease.