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目的 探讨原发性肾小球病变患者外周血粘附分子Ｐ选择素（ＣＤ６２Ｐ）与细胞表面糖蛋白（ＣＤ４４）的表达特征及其临床意义。方法 采用流式细胞术对９０例原发性肾小球肾炎患者外周血ＣＤ６２Ｐ和ＣＤ４４ 进行了检测分析，以３０例正常人作为对照。结果 原发性肾小球肾炎患者ＣＤ６２Ｐ和ＣＤ４４表达均较正常组显著增高（Ｐ＜ ０．０１），其中尿毒症组ＣＤ４４阳性细胞数增高极为显著，ＩｇＡ肾病组ＣＤ６２Ｐ和ＣＤ４４表达均较其它肾脏疾病组降低（Ｐ＜ ０．０５），ＣＤ６２Ｐ和ＣＤ４４表达为ｒ＝ ０．４１，呈正相关（Ｐ＜ ０．０５）。结论 ＣＤ６２Ｐ和ＣＤ４４ 在原发性肾小球病变患者外周血中表达异常，在肾脏疾病发展及病情变化过程中起重要作用。
Objective To investigate the expression and clinical significance of P-selectin (CD62P) and cell surface glycoprotein (CD44) in patients with primary glomerular disease. Methods Flow cytometry was used to detect CD62P and CD44 in peripheral blood of 90 patients with primary glomerulonephritis. Thirty normal controls were used as controls. Results The expressions of CD62P and CD44 in patients with primary glomerulonephritis were significantly higher than those in the normal group (P <0.01). The number of CD44 positive cells in the uremia group was significantly higher than that in the normal group. The expressions of CD62P and CD44 in IgA nephropathy group were significantly higher than those in other groups The disease group was lower (P <0.05), CD62P and CD44 expression was r = 0.41 (P <0.05). Conclusion CD62P and CD44 are abnormally expressed in the peripheral blood of patients with primary glomerular lesions and play an important role in the development of kidney disease and the progression of the disease.