【摘 要】
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Dear Editor,Voltage-gated sodium (Nav) channels are membrane proteins that are responsible for the propagation of action potentials in mammals by mediating Na+
【机 构】
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MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084,
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Dear Editor,Voltage-gated sodium (Nav) channels are membrane proteins that are responsible for the propagation of action potentials in mammals by mediating Na+ influx in excitable cells such as nerve and muscle.In human,Navchannels are therapeutic targets as their mutations contribute to many diseases.Structures of prekaryotic Nav channels,e.g.,NavAb (Payandeh et al.,2011),NavRh (Zhang et al.,2012) and NavMs (Mccusker et al.,2012),were successively determined in the past years.Recently,the cryo-EM structures of two eukaryotic Nav channels were reported (Shen et al.,2017;Yan et al.,2017).
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