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目的:探讨米非司酮预防子宫内膜息肉术后复发的效果。方法:选择行宫腔镜电切术后,经病理确诊为子宫内膜息肉患者168例,分为两组,治疗组87例予米非司酮10mg/d,连服3个月;对照组81例未服米非司酮。术后每个月记录月经量、血红蛋白浓度、子宫内膜厚度以及息肉复发情况。结果:所有病例术前和治疗后比较,月经量明显减少,血红蛋白浓度明显增加。组间比较,两组月经量、血红蛋白浓度、子宫内膜厚度、复发率差异有统计学意义(均P<0.05)。治疗组术后6、12、24个月比较子宫内膜厚度无明显增加(P>0.05)。结论:子宫内膜息肉术后服用米非司酮,能够抑制子宫内膜增生,降低子宫内膜息肉的复发率。
Objective: To investigate the effect of mifepristone in preventing postoperative recurrence of endometrial polyps. Methods: A total of 168 patients with endometrial polyps confirmed by pathology were divided into two groups. 87 patients in the treatment group were treated with mifepristone 10mg / d for 3 months. The control group 81 Cases did not take mifepristone. Month after menstruation records, hemoglobin concentration, endometrial thickness and polyp recurrence. Results: All cases before and after treatment, significantly reduced menstrual flow, hemoglobin concentration increased significantly. There was significant difference between groups in menstruation, hemoglobin concentration, endometrial thickness and recurrence rate (all P <0.05). There was no significant increase in endometrial thickness at 6, 12 and 24 months after operation in the treatment group (P> 0.05). Conclusion: Endometrial polyps after taking mifepristone can inhibit endometrial hyperplasia and reduce the recurrence rate of endometrial polyps.