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目的:探讨阴囊、阴茎Paget病的临床病理特点、诊断及鉴别诊断依据。方法:复习13例阴囊、阴茎Paget病的临床病理资料,采用HE染色、特殊染色(AB/PAS)及免疫组化技术进行观察分析。结果:阴囊、阴茎Paget病以老年男性多见,发病年龄55～84岁,中位年龄为71岁。肉眼皮损呈湿疹样改变。光镜下表皮内可见数目不等的Paget细胞呈单个散在、巢状或条索状分布。所有病例AB/PAS染色均阳性;13例均表达CK7、CEA、EMA抗原,不表达CK5/6、S-100及P63,GCDFP-15与CK20阳性表达率分别为76.92%(10/13)和53.85%(7/13)。结论:阴囊、阴茎Paget病为低度恶性的皮肤上皮性肿瘤,有特殊的临床及组织病理学特点,免疫组化标记有助于该肿瘤的诊断。
Objective: To investigate the clinical and pathological features of Paget’s disease in the scrotum and penis, and to provide evidences for diagnosis and differential diagnosis. Methods: The clinicopathological data of 13 cases of Paget disease of the scrotum and penis were reviewed and analyzed by HE staining, special staining (AB / PAS) and immunohistochemistry. Results: Scrotum and penis Paget disease is more common in older men, age of onset 55-84 years old, the median age was 71 years. Eyelid lesions showed eczema-like changes. Under the light microscope, the number of Paget cells in the epidermis showed a single scattered, nested or bar-like distribution. All cases were positive for AB / PAS staining; CK7, CEA and EMA antigens were expressed in 13 cases, but CK5 / 6, S-100 and P63 were not expressed in 13 cases, and positive rates of GCDFP-15 and CK20 were 76.92% 53.85% (7/13). Conclusion: The Paget’s disease of the scrotum and penis is a low-grade skin epithelial tumor with special clinical and histopathological features. Immunohistochemical markers are helpful to the diagnosis of this tumor.