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目的 :为探明妊高征血液流变学的变化规律 ,为预防和治疗提供依据。方法 :采用SA -B型体外血栓形成血小板粘附及可调恒压力毛细管粘度计 ,电脑自动测算。对 12 5例妊高征患者进行观察。结果 :①妊高征中期与晚期妊娠血液流变学 9项指标均呈上升趋势 ,其中纤维蛋白原 ,体外血栓长度、湿重、干重 ,血小板粘附率共 5项呈显著升高 ,P <0 .0 5～ 0 .0 1;②妊高征不同程度间血液流变学改变 :血球压积呈逐渐下降趋势 ,血小板粘附率呈逐渐升高趋势 ,两个指标轻度与重度差异显著 ,P <0 .0 5;③妊高征治疗前后血液流变学改变 :治疗后血球压积、全血粘度、血小板粘附率、血沉方程K等 4项呈下降趋势 ;其中血球压积及血沉方程K有显著性差异 ,分别P <0 .0 5～0 .0 1。结论 :血球压积与妊高征治疗密切相关 ;纤维蛋白原、体外血栓长度、湿重及干重 4项指标随着孕周的增加而逐渐增加 ,与妊高征的不同程度成正比 ,与治疗关系不明显 ;血小板粘附率的变化与不同孕期、不同程度密切相关。
Objective: To find out the change rule of hemorrheology in pregnancy induced hypertension and provide the basis for prevention and treatment. Methods: SA-B in vitro thrombosis platelet adhesion and adjustable constant pressure capillary viscometer, the computer automatically calculated. 125 cases of PIH were observed. Results: ①The indexes of hemorrheology in the middle and late pregnancy induced hypertension all tended to increase. Among them, fibrinogen, thrombus length in vitro, wet weight, dry weight and platelet adhesion rate were all significantly increased, P <0 .0 5 ~ 0 .0 1; ②Hepatheological changes in different degrees of PIH: The hematocrit decreased gradually, the rate of platelet adhesion increased gradually, the mild and severe difference between the two indexes P <0. 05; ③ Hemorheological changes before and after pregnancy-induced hypertension: after treatment, hematocrit, whole blood viscosity, platelet adhesion rate, and Erythrocyte equation K showed a downward trend; of which hematocrit And erythrocyte sedimentation rate K were significantly different, respectively, P <0.05 ~ 0. 01. Conclusion: The hematocrit is closely related to the treatment of PIH. The indexes of fibrinogen, length of thrombus in vitro, wet weight and dry weight increase gradually with the increase of gestational age, which is directly proportional to the degree of PIH, The relationship between treatment is not obvious; changes in platelet adhesion rate and different pregnancy, are closely related to different degrees.