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目的了解耐碳青霉烯类肠杆菌科细菌(CRE)分布情况,为医院CRE感染预防控制工作提供参考。方法收集嘉兴市第一医院2012—2016年6月临床微生物实验室检出的CRE患者相关资料,包括性别、年龄、科室、主要疾病诊断、住院时间和疾病转归,分析CRE检出率。结果 2012—2016年6月共检出肠杆菌科细菌17 383株,检出CRE 646株,检出率为3.72%,且呈逐年上升趋势(P<0.05)。检出CRE感染的患者主要分布在重症医学科和神经外科,不同科室CRE检出率差异有统计学意义(P<0.05)。CRE患者的住院时间和死亡率均高于非CRE感染患者(P<0.05)。检出CRE的前5位细菌分别是肺炎克雷伯菌、大肠埃希菌、奇异变形杆菌、阴沟肠杆菌和粘质沙雷菌。结论 CRE的检出率呈逐年上升趋势,应加强医院CRE感染的预防控制工作。
Objective To understand the distribution of carbapenem-resistant Enterobacteriaceae (CRE) and provide references for the prevention and control of CRE infection in hospitals. Methods The data of CRE patients detected by clinical microbiology laboratory in the First Hospital of Jiaxing City from 2012 to June 2016 were collected, including sex, age, department, diagnosis of major diseases, length of hospital stay and disease outcome, and the detection rate of CRE was analyzed. Results A total of 17 383 Enterobacteriaceae isolates were detected from 2012 to June 2016, and CRE 646 strains were detected, with a detection rate of 3.72%, showing an upward trend year by year (P <0.05). The patients with CRE infection were mainly found in the intensive care department and neurosurgery. There was significant difference in CRE detection rate among different departments (P <0.05). The duration of hospital stay and mortality in CRE patients were higher than those in non-CRE patients (P <0.05). The top 5 bacteria that detected CRE were Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Enterobacter cloacae, and Serratia marcescens. Conclusion The detection rate of CRE has been increasing year by year, and the prevention and control of CRE infection in hospitals should be strengthened.