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目的合成鬼臼毒素聚合物胶团,评价其对人胶质瘤细胞的增殖抑制作用。方法制备鬼臼毒素聚合物胶团,考察其理化性质,通过肿瘤细胞摄取实验,噻唑蓝(MTT)法检测其对U87细胞的增殖抑制作用。结果鬼臼毒素聚合物胶团比游离药物鬼臼毒素对人胶质瘤细胞有更大的增殖抑制作用,显著增加肿瘤细胞内的药物浓度。结论鬼臼毒素聚合物胶团对人脑胶质瘤细胞增殖有明显的抑制作用。
Objective To synthesize podophyllotoxin polymer micelles and evaluate its inhibitory effect on the proliferation of human glioma cells. Methods The podophyllotoxin polymer micelles were prepared and their physical and chemical properties were investigated. Tumor cell uptake assay and MTT assay were used to detect the proliferation inhibition of U87 cells. Results podophyllotoxin polymer micelles than free drug podophyllotoxin on human glioma cells have a greater inhibition of proliferation, significantly increase the concentration of drug in tumor cells. Conclusion podophyllotoxin polymer micelles significantly inhibit the proliferation of human glioma cells.