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机体产生抗体的强度,一方面因动物的种类、年龄、营养状况及受刺激部位的感受性而不同,另一方面则与为免疫用的抗原的性质、应用剂量、注射途径及注射的间隔期有关。作者等在制备沉淀血清时,充分地证实了抗原血清之性质、注射剂量、注射次数、免疫途径、注射间隔期等因素对沉淀血清的效价、特异性以及高效价维持的久暂有密切的关系(1,2,3,4)。此外,还证明采用不同部位的静脈或动脈作为注射途径,所激生的沉淀血清的效价和高效价的维持时期亦不相同。在进行上述一系列的实验中,还发现了另一个有兴趣的事实,那就是不同免疫途径的交替应用,可以提高沉淀血清的效价以及延长高效价在机体内维持的期限。今将结果简单报道以求正于同道。
The strength of an antibody produced by the body varies depending on the animal’s type, age, nutritional status and susceptibility to the site of stimulation, on the one hand, and on the other hand the nature of the antigen for immunization, the dose applied, the route of administration and the interval between injections . When preparing precipitated serum, the authors fully substantiated the long-term and long-term effects of precipitated serum on the titer, specificity and high titer of the serum, such as the nature of the antigen serum, the dose of injection, the number of injections, the immunization route, and the injection interval. Relationship (1,2,3,4). In addition, it has also been demonstrated that the use of different parts of the vein or artery as the injection route, the activated serum sediment titer and high titer maintenance period is not the same. In conducting the above series of experiments, another interesting fact was found that the alternating application of different immunization routes could increase the titer of precipitated serum and prolong the duration of high titer maintenance in the body. This result will be simply reported in order to seek positive fellow.