,Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients

• 作 者: Lin-yong XU Yi-jing HE Wei ZHANG Sheng Deng Qing LI Wei-xia ZHANG Zhao-qian LIU Dan WANG Yuan-fei HUANG Hong-hao ZHOU Zhen-qiu SUN
• 机 构: Department of Epidemic and Health Statistics, School of Public Health, Central South University, Cha
• 出 处: 中国药理学报(英文版)
• 发表日期: 2007年10期
• 关键词: organic anion transporting polypeptide-IB 1 388G>A 521T>C genotyping Chine

Aim: To detect 388G>A and 521T>C variant alleles in the organic anion transporting polypeptide- 1B 1 (OATP 1B 1, encoding gene SLCOIB1) gene. Methods:One hundred and eleven healthy volunteers were screened for OATPIB 1 alleles in our study. PCR-restriction fragment length polymorphism was used to identify the 388G>A polymorphism and a 1-step tetra-primer method was developed for the determination of 521T>C mutation. Results: The frequencies of the 388G>A and 521T>C variant alleles in the Chinese population were 73.4%and 14.0%,respectively. The frequencies of the SLCO1BI*lb and *15 haplotypes were 59.9% and 14.0%, respectively. Conclusion: The SLCO1B1*1b and SLCO1B1*15 variants are relatively common in the Chinese population. Their frequencies are similar to that in the Japanese, but significantly different from that in Caucasians and blacks.