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目的:评价抗甲状腺药物用于治疗妊娠“甲亢”患者对新生儿甲状腺功能的影响。方法:选取2014年7月—2015年7月间收治的妊娠“甲亢”患者90例,采用随机数字法将其分为对照组45例和观察组45例;对照组患者均给予非抗甲状腺药物(如放射典或手术治疗)治疗,观察组患者均给予丙基硫氧嘧啶治疗,比较两组患者治疗后对妊娠患者不良反应(或结局)的发生率,以及对新生儿甲状腺功能各指标的影响。结果:观察组患者治疗后不良反应(或结局)的发生率明显高于对照组(P<0.05);用药后观察组患者的新生儿甲状腺各项功能指标明显优于对照组(P<0.05)。结论:采用丙基硫氧嘧啶治疗妊娠“甲亢”患者,不良反应(或结局)的发生率明显低于对照组,能降低了妊娠结局的发生率,改善了新生儿甲状腺功能。
Objective: To evaluate the effect of antithyroid drugs on neonatal thyroid function in patients with gestational “hyperthyroidism”. Methods: Totally 90 pregnant women with “hyperthyroidism” who were admitted between July 2014 and July 2015 were randomly divided into control group (45 cases) and observation group (45 cases). Patients in the control group were given non-anti Thyroid drugs (such as radiotherapy or surgical treatment), the observation group were given propylthiouracil treatment, the two groups of patients treated after treatment of adverse reactions (or outcome) incidence, as well as neonatal thyroid function The impact of indicators. Results: The incidence of adverse reactions (or outcomes) in observation group was significantly higher than that in control group (P <0.05). After treatment, the functional indexes of neonates with thyroid in observation group were significantly better than those in control group (P <0.05) . Conclusions: The incidence of adverse reactions (or outcomes) in patients with pregnancy “hyperthyroidism” treated with propylthiouracil is significantly lower than that of the control group, which can reduce the incidence of pregnancy outcomes and improve the neonatal thyroid function.