论文部分内容阅读
目的:探讨聚乙二醇-20000对阿糖胞苷脂质体载药性能的影响。方法:用蛋黄卵磷脂为包封材料,采用逆相蒸发法制备阿糖胞苷脂质体,用不同质量浓度的聚乙二醇包覆进行表面修饰,与未包覆的脂质体进行对照,通过测定其包封率、平均粒径、粒度分布及药物的渗漏速率,对聚乙二醇-20000修饰的阿糖胞苷脂质体的载药性能进行评价。结果:聚乙二醇-20000修饰的阿糖胞苷脂质体具有较高的包封率、较大的平均粒径和较低的渗漏速率。ρ(PEG)=2.0g/L时,包封率最高为(22.34±2.47)%,平均粒径最大为5.99μm。ρ(PEG)=4.0g/L时,渗漏速率最慢。结论:聚乙二醇-20000的修饰提高了阿糖胞苷脂质体的载药性能。
Objective: To investigate the effect of polyethylene glycol-20000 on drug loading of cytarabine liposomes. METHODS: Cytarabine liposomes were prepared by reverse phase evaporation with egg yolk lecithin as encapsulating material, and then surface modified with different concentrations of polyethylene glycol to control the uncoated liposomes , The encapsulation efficiency, average particle size, particle size distribution and the leakage rate of the drug were measured to evaluate the drug-loading performance of the polyethylene glycol-20000-modified cytarabine liposome. Results: Polyethylene glycol-20000 modified cytarabine liposomes have higher encapsulation efficiency, larger average particle size and lower leakage rate. The highest entrapment efficiency was (22.34 ± 2.47)% and the average particle size was 5.99μm at ρ (PEG) = 2.0g / L. The leakage rate was the slowest when ρ (PEG) = 4.0g / L. Conclusion: The modification of PEG-20000 enhances the drug-loading ability of cytarabine liposomes.