论文部分内容阅读
目的:探讨将家族史联合肥胖用于筛查儿童血脂紊乱的意义。方法:通过整群抽样方法对北京地区6~18岁儿童青少年进行横断面流行病学调查。有效调查对象19037例,其中男童9495人,女童9542人,根据年龄及性别分为学龄期男童、青春期男童、学龄期女童和青春期女童。检测受试儿童空腹末梢血总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)以及身高、体重并计算体重指数。结果:在总受试儿童中,有家族史儿童占38%,肥胖儿童占4.9%,有家族史并肥胖儿童占2.5%,有家族史或肥胖儿童占40.4%。无肥胖且无家族史儿童、无肥胖但有家族史儿童、肥胖但无家族史儿童及肥胖且有家族史儿童各种血脂异常发生率分别为:高脂血症7.9%、9.6%、30.1%及31.5%;高胆固醇血症0.9%、1.5%、3.3%及2.9%;高甘油三酯血症7.1%、8.6%、29.2%及31.3%;混合型高脂血症0.2%、0.5%、0.4%及2.7%。肥胖儿童发生血脂紊乱的危险性与非肥胖儿童相比各性别年龄分组OR值(95%可信区间)分别为:学龄期男童6.439(4.178~9.925)、青春期男童6.287(4.153~9.518)、学龄期女童5.063(3.041~8.427)、青春期女童3.665(2.536~5.296)(P均=0.000)。有家族史儿童发生血脂紊乱的危险性与无家族史儿童相比各性别年龄分组OR值(95%可信区间)分别为:学龄期男童1.204(0.952~1.522)(P=0.121)、青春期男童1.331(1.047~1.692)(P=0.020)、学龄期女童1.095(0.847~1.416)(P=0.490)、青春期女童1.260(1.070~1.483)(P=0.005)。在血脂紊乱儿童中,有家族史儿童占43.8%,肥胖儿童占15.8%,有家族史并肥胖儿童占8.2%,有家族史或肥胖儿童占51.3%。结论:家族史联合肥胖对于筛查儿童血脂紊乱有重要意义。
Objective: To explore the significance of using family history combined with obesity in screening children for dyslipidemia. Methods: The cross-sectional epidemiological investigation of adolescents aged 6 to 18 in Beijing was conducted by cluster sampling method. There are 19,037 valid respondents, of whom 9,495 are boys and 9,542 are girls. According to their age and sex, they are divided into school-age boys, adolescent boys, school girls and adolescent girls. The fasting blood total cholesterol (TC), triglyceride (TG) and height and weight were measured and the body mass index (BMI) was calculated. RESULTS: Of the total children tested, 38% had pedigrees, 4.9% had obese children, 2.5% had a family history of obesity, and 40.4% had a family history or obese children. The incidence of various dyslipidemia in children without obesity and family history without obesity but with family history, obesity but without family history and children with family history of obesity were: hyperlipidemia 7.9%, 9.6%, 30.1% And 31.5% respectively; hypercholesterolemia 0.9%, 1.5%, 3.3% and 2.9%; hypertriglyceridemia 7.1%, 8.6%, 29.2% and 31.3%; mixed hyperlipidemia 0.2%, 0.5% 0.4% and 2.7%. The risk of dyslipidemia in obese children Compared with non-obese children, the odds ratios (95% confidence intervals) of boys in school age were 6.439 (4.178-9.925) in school age and 6.287 (4.153-9.518) in adolescent boys , 5.063 (3.041 ~ 8.427) in school-age girls, and 3.665 (2.536 ~ 5.296) in adolescent girls (P = 0.000). Risk of dyslipidemia in children with a family history Compared with children without a family history, the odds ratios (95% confidence interval) of boys in school age were 1.204 (0.952-1.522) (P = 0.121), puberty Boys 1.331 (1.047-1.692) (P = 0.020), 1.095 (0.847-1.416) girls in school age and 1.260 (1.070-1.483) in adolescent girls (P = 0.005). Among children with dyslipidemia, 43.8% have family history of children, 15.8% have obese children, 8.2% have obesity children with family history, and 51.3% have family history or obese children. Conclusion: Family history combined with obesity is of great significance in screening children for dyslipidemia.