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引言四环素族是最老的一族抗生素(事实上,它们是四十年代后问世的)。然而,至今仍被广泛地使用着。它之所以能应用这么久是由这族抗生素的特性所决定的,即它们具有广谱、低毒、几乎没有过敏反应(仅有极少量的光敏反应发生)、口服后吸收良好和成本低廉。四环素族抗生素的主要缺点是在含钙的组织中的沉积作用,从而污染和损坏骨骼和牙齿(因此,四环素族不宜于孕妇和12岁以下的儿童使用)。耐药性不时地发展也是它们的主要问题。自1950年至今,人们在四环素族方面做
Introduction Tetracyclines are the oldest family of antibiotics (in fact they came out after the 1940s). However, it is still widely used today. The reason why it can be applied for so long is governed by the characteristics of this group of antibiotics, that is, they are broad-spectrum, low-toxic, have almost no allergic reaction (only a very small amount of photoreaction), good absorption after oral administration, and low cost. The major drawback of tetracycline antibiotics is the sedimentation in calcium-containing tissues, which can contaminate and damage bones and teeth (therefore tetracyclines are not recommended for pregnant women and children under 12 years of age). The development of drug resistance from time to time is also their main problem. Since 1950, people have done in Tetracyclines