将内皮祖细胞纳入心血管疾病治疗方案的争论与探讨

• 作 者: 徐倩 曹荟哲 哈小琴
• 机 构: 兰州大学第二附属医院,兰州理工大学,兰州军区兰州总医院检验科,
• 出 处: 临床心血管病杂志
• 发表日期: 2016年10期
• 关键词: endothelial progenitor cells endothelial cells cardiovascular diseases vascular

内皮祖细胞(EPCs)对受损血管的修复和新血管的形成至关重要。机体缺血或血管损伤时,EPCs可直接分化为成熟的内皮细胞(ECs)或分泌多种细胞因子促进血管的修复和新生。心血管疾病(CVD)的发生与体内EPCs的数量和功能密切相关,有建议认为可将其作为CVD的临床生物标志物。然而,目前关于EPCs的定义及其鉴定方法尚未标准化,因此关于将其作为CVD标志物值得探讨。

Endothelial progenitor cells (EPCs) are crucial for the repair of damaged blood vessels and the formation of new blood vessels. EPCs can directly differentiate into mature endothelial cells (ECs) or secrete a variety of cytokines to promote the repair and neovascularization of blood vessels in body ischemia or vascular injury. The occurrence of cardiovascular disease (CVD) is closely related to the quantity and function of EPCs in vivo. It has been suggested that it can be used as a clinical biomarker of CVD. However, the current definition of EPCs and their identification methods have not been standardized, so it is worth discussing as a CVD marker.