论文部分内容阅读
综述了近年来鎓盐类多肽缩合剂在有机合成中应用的研究进展。鎓盐类多肽缩合剂主要分为两大类:磷正离子缩合剂和脲正离子缩合剂,由于其发展迅速,不仅改良了传统的鎓盐类缩合剂,扩展了鎓盐类多肽缩合剂的种类,而且出现了新型的盐类缩合剂,如亚胺正离子型缩合剂等。这类缩合剂不仅可以用于酯和酰胺的合成,而且可以用于合成小肽和生物活性肽,从而扩展到整个有机合成领域。
The progress in the application of onium salt peptide condensate in organic synthesis is reviewed. Onium salt polypeptide condensing agent is mainly divided into two categories: phosphorus positive ion condensate and urea positive ion condensate, due to its rapid development, not only improved the traditional onium salt condensate, extended onium salt polypeptide condensate Species, but also a new type of salt condensate, such as imine positive ion condensate. Such condensing agents can be used not only in the synthesis of esters and amides, but also in the synthesis of small peptides and bioactive peptides, thereby extending the field of organic synthesis.