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以２４４株革兰氏阳性球菌为实验菌株，红霉素、罗红霉素、ａｚｉｔｈｒｏｍｙｃｉｎ（ＡＺＭ）、交沙霉素为代表药物，通过试管对倍稀释法测定大环内酯类抗生素对革兰氏阳性球菌的最低抑菌浓度，评价其体外抗菌活性。结果显示：大环内酯类抗生素对葡萄球菌属细菌的ＭＩＣ５０为０．５～２μｇ／ｍｌ，ＭＩＣ９０为２～１６μｇ／ｍｌ，对链球菌属细菌的ＭＩＣ５０为０．１２５～２μｇ／ｍｌ，ＭＩＣ９０为０．２５～４μｇ／ｍｌ，ＡＺＭ对葡萄球菌属细菌的ＭＩＣ９０为２～４μｇ／ｍｌ，对链球菌属细菌的ＭＩＣ９０为０．５μｇ／ｍｌ，罗红霉素则分别为４和０．１２５～０．２５μｇ／ｍｌ，红霉素分别为８～１６及０．５～１μｇ／ｍｌ，交沙霉素则分别为４～１６及０．５～４μｇ／ｍｌ，表明ＡＺＭ、罗红霉素抗菌活性相似，优于红霉素及交沙霉素，但ＡＺＭ、罗红霉素与红霉素存在交叉耐药性，而交沙霉素对部分耐红霉素的菌株仍有抗菌活性，大环内酯类抗生素对链球菌属细菌的抗菌活性强于对葡萄球菌属者，肠球菌对大环内酯类抗生素呈现耐药性。
244 strains of gram-positive cocci as experimental strains, erythromycin, roxithromycin, azithromycin (AZM), jasminemycin as the representative drug, through the test tube doubling dilution method to determine the effect of macrolide antibiotics on Gram The minimum inhibitory concentration of positive cocci, evaluation of its in vitro antibacterial activity. The results showed that the MIC50 of macrolide antibiotics to Staphylococcus was 0.5-2μg / ml, MIC90 was 2-16μg / ml, the MIC50 of Streptococcus was 0.125-2μg / ml, the MIC90 Was 0.25-4 μg / ml, the MIC90 of AZM to Staphylococcus was 2-4 μg / ml, that of Streptococcus was 0.5 μg / ml, and that of roxithromycin was 4 and 0.125, respectively ~ 0.25μg / ml, erythromycin respectively 8-16 and 0.5-1μg / ml, jasamycin respectively 4-16 and 0.5-4μg / ml, indicating that AZM, roxithromycin Antibacterial activity similar to, better than erythromycin and jasminemycin, but AZM, roxithromycin and erythromycin cross-resistant, and jasamycin on erythromycin-resistant strains still antibacterial activity, The antibacterial activity of macrolide antibiotics on Streptococcus was stronger than those on Staphylococcus, and the antibiotics of macrolide against Enterococcus were Resistance.