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【目的】探讨脑干听觉诱发电位(brainstem auditory evoked potential,BAEP)对于巨细胞病毒(cytomegalo-virus,CMV)感染所致的听力异常的早期诊断价值。【方法】选取了200例在中国医科大学附属盛京医院2010年10月-2012年6月间经病原学诊断为CMV感染的婴幼儿进行BAEP的测定。【结果】1)Ⅴ波反应阈异常者68例,共122耳,其中轻度异常100耳(占82%),中度异常17耳(占13.9%),重度异常5耳(占4.1%);2)BAEP异常表现:Ⅰ波消失20耳(占16.4%),Ⅲ波潜伏期延长24耳(占19.7%),Ⅲ～Ⅴ峰间潜伏期延长34耳(27.9%),Ⅰ、Ⅲ、Ⅴ波同时消失6耳(占4.9%);3)Ⅴ波反应阈异常患儿中男性有40例(占20%),女性28例(占14%)。Ⅴ波反应阈异常无性别差异;4)≤3月患儿236耳,听反应阈异常者87耳(36.9%);3～5月患儿86耳,异常者16耳(18.6%);>5月患儿78耳,异常者19耳(24.4%)。月龄越小,BAEP异常率越高。【结论】CMV感染患儿应常规行BAEP检查,可早期发现是否有听力异常及听力异常的程度和性质。
【Objective】 To investigate the early diagnostic value of brainstem auditory evoked potential (BAEP) for hearing loss caused by cytomegalo-virus (CMV) infection. 【Methods】 A total of 200 cases of infants and young children diagnosed as CMV infection by etiology at Shengjing Hospital Affiliated to China Medical University from October 2010 to June 2012 were enrolled in this study. 【Results】 1) There were 68 cases with abnormal response threshold of V wave, 122 ears in total, including 100 ears (82%), 17 ears (13.9%), 5 ears (4.1%), ; 2) BAEP abnormalities: Ⅰ wave disappeared 20 ears (16.4%), Ⅲ wave latency extended 24 ears (19.7%), Ⅲ ~ Ⅴ extended 34 ears (27.9% There were 40 males (20%) and 28 females (14%) with V wave abnormalities. There was no gender difference in Ⅴ wave response threshold; 4) 236 ears ≤ ≤ 3 months, 87 ears (36.9%) with abnormal reaction threshold, 86 ears (3-5 ears) and 16 ears (18.6% May 78 cases of children with abnormalities in 19 ears (24.4%). The younger age, the higher the abnormal rate of BAEP. 【Conclusions】 Children with CMV infection should be routinely examined with BAEP, and whether or not they have hearing impairment and abnormal hearing can be detected early.