一项硫酸镁治疗重度先兆子痫的前瞻性随机试验:采用利尿现象作为临床参考指标确定产后治疗持续时间

• 作 者: Fontenot M.T Lewis D.F Frederick J.B 朱国栋
• 机 构: 17807 Arbor Haven Dr Tampa,FL 33647 United States.Dr,
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2005年10期
• 关键词: 前瞻性随机试验 硫酸镁治疗 重度先兆子痫 持续时间 抗高血压治疗 产妇 精确检验 统计学数据 尿量 疾病严重程度

Objective: The purpose of this study was to assess the use of the onset of diuresis in the determination of the duration of postpartum magnesium sulfate therapy among patients with severe preeclampsia. Study design: A prospective randomized trial of postpartum therapy with magnesium sulfate was conducted. The control group received 24 hours of therapy, and the study group received therapy until the onset of diuresis (urine output >100 mL/h for 2 consecutive hours). The Student t test, χ 2 test, and Fisher’s exact test were used for analysis of data; a probability value of < .05 was considered statistically significant. Results: There were 50 patients in the control group and 48 patients in the study group. There was no difference in maternal demographic data, severe disease criteria, blood pressure, 24- hour postpartum urine output, or need for antihypertensive therapy. The study group had a significantly shorter duration of therapy, and no patient had eclampsia or required the re- initiation of therapy. Conclusion: The use of the onset of diuresis in the postpartum period as the determinant clinical parameter for the discontinuation of magnesium sulfate in patients with severe preeclampsia was associated with no untoward outcomes or need for the re- initiation of treatment.

Objective: The purpose of this study was to assess the use of the onset of diuresis in the determination of the duration of postpartum magnesium sulfate therapy among patients with severe preeclampsia. Study design: A prospective randomized trial of postpartum therapy with magnesium sulfate was conducted. The control group received 24 hours of therapy, and the study group received therapy until the onset of diuresis (urine output> 100 mL / h for 2 consecutive hours). The Student t test, χ 2 test, and Fisher’s exact test were used for There was 50 difference in maternal demographic data, severe disease criteria, blood pressure, 24-hour postpartum urine output, or need for antihypertensive therapy. The study group had a significant shorter duration of therapy, and no patient had eclampsia or required the re- in Conclusion: The use of the onset of diuresis in the postpartum period as the determinant clinical parameter for the discontinuation of magnesium sulfate in patients with severe preeclampsia was associated with no untoward outcomes or need for the re- initiation of treatment.