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目的利用酰胺质子转移(APT)磁共振技术探讨不同分期帕金森病(PD)患者黑质APT信号的特征,并与正常对照者进行比较。方法对21名正常对照者(男12名,女9名,年龄56~75岁)和65例PD患者(男35例,女30例,年龄52~76岁)进行头部APT磁共振成像,测量双侧黑质的酰胺质子不对称磁化转移率(MTR_(asym))。将PD患者根据发病时间分为早期、中期和晚期(发病时间分别为≤1年、2~5年、≥6年),采用方差分析比较不同分期PD患者及正常对照者黑质MTR_(asym)(3.5 ppm)是否存在差异。结果 65例PD患者中,早期20例,中期22例,晚期23例,其黑质的MTR_(asym)(3.5ppm)分别为(1.17±0.15)%、(1.04±0.12)%及(0.88±0.17)%,均显著低于正常对照组(1.40±0.18)%(P值分别为0.038、0.001及<0.001)。结论磁共振APT成像信号有可能成为诊断PD患者的可靠分子标记物。
OBJECTIVE: To investigate the characteristics of APT signal in substantia nigra of patients with different stages of Parkinson’s disease (PD) by using amide proton transfer (APT) magnetic resonance imaging technique and compare with normal controls. Methods A total of 21 normal control subjects (12 males, 9 females, 56-75 years of age) and 65 PD patients (35 males and 30 females, aged 52-76 years) Amide proton asymmetric magnetization transfer rate (MTR_ (asym)) of bilateral substantia nigra was measured. PD patients were divided into early stage, middle stage and advanced stage according to the onset time (onset time ≤ 1 year, 2 to 5 years, ≥ 6 years) .Analysis of variance was used to compare the substantia nigra MTR asym from PD patients with different stages and normal controls (3.5 ppm) is there any difference. Results Among the 65 PD patients, 20 (early), 22 (middle) and 23 late (late) patients had a mean of 1.17 ± 0.15%, 1.04 ± 0.12% and 0.88 ± 0.17)%, respectively, which were significantly lower than that of the normal control group (1.40 ± 0.18)% (P = 0.038,0.001 and <0.001, respectively). Conclusion Magnetic resonance imaging of APT may become a reliable molecular marker for the diagnosis of PD.